- Safety Harbor (1,170 Companies)
- Saint Augustine (11,460 Companies)
- Saint Augustine Beach (12 Companies)
- Saint Cloud (4,065 Companies)
- Saint James City (329 Companies)
- Saint Johns (1,576 Companies)
- Saint Leo (13 Companies)
- Saint Lucie (1 Company)
- Saint Lucie West (2 Companies)
- Saint Marks (28 Companies)
- Saint Pete Beach (92 Companies)
- Saint Petersburg (26,529 Companies)
- Salem (2 Companies)
- Salt Springs (5 Companies)
- San Antonio (335 Companies)
- San Mateo (74 Companies)
- Sand Lake (2 Companies)
- Sanderson (89 Companies)
- Sandestin (6 Companies)
- Sanford (8,070 Companies)
- Sanibel (1,138 Companies)
- Santa Rosa Beach (2,357 Companies)
- Sarasota (31,878 Companies)
- Satellite Beach (1,787 Companies)
